TScan Therapeutics highlights push into in vivo-engineered TCR-T cell therapy for solid tumors in corporate presentation
Reuters2026/09/02 11:14- TScan outlined a strategic pivot toward in vivo-engineered TCR-T cell therapies for solid tumors, centered on a T-cell targeted lentiviral platform.
- Two in vivo TCR-T candidates advanced into IND-enabling work, prioritizing PRAME and MAGE-A4 programs for solid tumor indications.
- Key timeline: preclinical data and regulatory updates in Q1 2027, first IND filing in Q3 2027, Phase 1 trial start in Q4 2027.
- Phase 3 solid tumor study paused to allow data to mature, while the company pursues external manufacturing and a strategic partnership.
- Heme malignancies and autoimmunity programs put on hold pending partnership, with patients continuing follow-up in ALLOHA and ALLOHA-2 studies.
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